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New Issue Volume 83, Issue 4 / 2021

Photobiomodulation of the Brain: Shining Light on Alzheimer's and Other Neuropathological Diseases

Guest Editors: Michael R. Hamblin and Farzad Salehpouru

Introduction Extract:
"Photobiomodulation (PBM) therapy refers to the non-thermal use of visible to near-infrared light to stimulate many biological processes. Brain PBM therapy is a promising modality by which light emitted by lasers or light emitting diodes is delivered to the scalp to stimulate neural cells and brain function. It is well known that photons in this wavelength range are able to penetrate the scalp/skull and partially reach the brain tissue. There is growing preclinical evidence to support the hypothesis that brain PBM therapy could ameliorate neuronal oxidative stress, neuroinflammation, and apoptosis, and could also stimulate neurogenesis and synaptogenesis. The aim of this mini-forum is to present the current state of the art in the application of photobiomodulation therapy for dementia, Alzheimer’s disease, and other brain conditions."

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Indexed in: PubMed/MEDLINE Web of Science Scopus

Volume 83, Issue 4 / 2021 Online

INTRODUCTION
Photobiomodulation of the Brain: Shining Light on Alzheimer’s and Other Neuropathological DiseasesOpenly Available
Hamblin, Michael R. | Salehpour, Farzad

REVIEW ARTICLE
Exploring the Use of Intracranial and Extracranial (Remote) Photobiomodulation Devices in Parkinson’s Disease: A Comparison of Direct and Indirect Systemic Stimulations
Johnstone, Daniel M. | Hamilton, Catherine | Gordon, Luke C. | Moro, Cecile | Torres, Napoleon | Nicklason, Frank | Stone, Jonathan | Benabid, Alim-Louis | Mitrofanis, John

RESEARCH ARTICLES
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model
Yang, Luodan | Wu, Chongyun | Tucker, Lorelei | Dong, Yan | Li, Yong | Xu, Peisheng | Zhang, Quanguang

Photobiomodulation Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies
Salehpour, Farzad | Khademi, Mahsa | Hamblin, Michael R.

Dosimetry and Clinical Efficacy of Transcranial Photobiomodulation for Major Depression Disorder: Could they Guide Dosimetry for Alzheimer’s Disease?
Caldieraro, Marco Antonio | Laufer-Silva, Tatiana | Cassano, Paolo

Photobiomodulation Enhances Memory Processing in Older Adults with Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy Study
Chan, Agnes S. | Lee, Tsz-lok | Hamblin, Michael R. | Cheung, Mei-chun

Pilot Study on Dose-Dependent Effects of Transcranial Photobiomodulation on Brain Electrical Oscillations: A Potential Therapeutic Target in Alzheimer’s Disease
Spera, Vincenza | Sitnikova, Tatiana | Ward, Meredith J. | Farzam, Parya | Hughes, Jeremy | Gazecki, Samuel | Bui, Eric | Maiello, Marco | De Taboada, Luis | Hamblin, Michael R. | et al.

Exploring the Effect of Combined Transcranial and Intra-Oral Photobiomodulation Therapy Over a Four-Week Period on Physical and Cognitive Outcome Measures for People with Parkinson’s Disease: A Randomized Double-Blind Placebo-Controlled Pilot Study
Bullock-Saxton, Joanne | Lehn, Alexander | Laakso, E-Liisa

Effects of Photobiomodulation on Changes in Cognitive Function and Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment: A Pilot Uncontrolled Trial
Baik, Ji Soo | Lee, Tae Young | Kim, Nam Gyun | Pak, Kyoungjune | Ko, Sung-Hwa | Min, Ji Hong | Shin, Yong-Il

Effects of Morning Blue-Green 500 nm Light Therapy on Cognition and Biomarkers in Middle-Aged and Older Adults with Subjective Cognitive Decline and Mild Cognitive Impairment: Study Protocol for a Randomized Controlled Trial
Wang, Ziqi | Zhang, Yige | Dong, Li | Zheng, Zihao | Zhong, Dayong | Long, Xunqin | Cai, Qingyan | Jian, Wei | Zhang, Songge | Wu, Wenbin | Yao, Dezhong

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Indexed in: PubMed/MEDLINE Web of Science Scopus

NEW ISSUE: REGULAR CONTENT

Volume 83, Issue 4 / 2021 Online

REVIEW ARTICLES
A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer’s Disease
Mukhopadhyay, Sanchari | Banerjee, Debanjan

The Role of Thyroid Function in Alzheimer’s Disease
Ge, Feifei | Zhu, Donglin | Tian, Minjie | Shi, Jingping

Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental Disorders Through Neurotech Innovations and Policies
Morris, Kevin | Nami, Mohammad | Bolanos, Joe F. | Lobo, Maria A. | Sadri-Naini, Melody | Fiallos, John | Sanchez, Gilberto E. | Bustos, Teshia | Chintam, Nikita | Amaya, Marco | et al.

COVID-19 CONTENT
High Exhaustion in Geriatric Healthcare Professionals During the COVID-19 Second LockdownOpenly Available
El Haj, Mohamad | Allain, Philippe | Annweiler, Cédric | Boutoleau-Bretonnière, Claire | Chapelet, Guillaume | Gallouj, Karim | Kapogiannis, Dimitrios | Roche, Jean | Boudoukha, Abdel Halim

EDITOR'S CHOICE RESEARCH ARTICLES
Preventing Delirium and Promoting Long-Term Brain Health: A Clinical Trial Design for the Perioperative Cognitive Enhancement (PROTECT) Trial
Atkins, Kelly J. | Scott, David A. | Silbert, Brendan | Pike, Kerryn E. | Evered, Lis

Incremental Healthcare Utilization and Cost Burden of Comorbid Insomnia in Alzheimer’s Disease PatientsOpen Access
Qureshi, Zaina P. | Thiel, Ellen | Nelson, James | Khandker, Rezaul

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New Issue Volume 83, Issue 3

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Indexed in: PubMed/MEDLINE Web of Science Scopus

NEW ISSUE

Volume 83, Issue 3 / 2021 Online

REVIEW ARTICLES
NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s DiseaseOpen Access
Van Zeller, Mariana | Dias, Diogo | Sebastião, Ana M. | Valente, Cláudia A.

Gut Microbiota and Alzheimer’s Disease: Pathophysiology and Therapeutic Perspectives
Li, Yanli | Wang, Rui | Li, Qian | Wang, Yan-Jiang | Guo, Junhong

A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s DiseaseOpen Access
Cioffi, Federica | Adam, Rayan Hassan Ibrahim | Bansal, Ruchi | Broersen, Kerensa

Pain and Associated Neuropsychiatric Symptoms in Patients Suffering from Dementia: Challenges at Different Levels and Proposal of a Conceptual FrameworkOpen Access
Kaufmann, Liane | Moeller, Korbinian | Marksteiner, Josef

EDITOR'S CHOICE RESEARCH ARTICLES
Taking the A Train? Limited Consistency of Aβ42 and the Aβ42/40 Ratio in the AT(N) Classification
Gouilly, Dominique | Tisserand, Camille | Nogueira, Leonor | Saint-Lary, Laura | Rousseau, Vanessa | Benaiteau, Marie | Rafiq, Marie | Carlier, Jasmine | Milongo-Rigal, Emilie | et al.

Mutations in the Amyloid-β Protein Precursor Reduce Mitochondrial Function and Alter Gene Expression Independent of 42-Residue Amyloid-β Peptide
Pope, Chad A. | Wilkins, Heather M. | Swerdlow, Russell H. | Wolfe, Michael S.

A Cost-Consequence Analysis of Different Screening Procedures in Alzheimer’s Disease: Results from the MOPEAD ProjectOpen Access
Wimo, Anders | Belger, Mark | Bon, Jaka | Jessen, Frank | Dumas, Annette | Kramberger, Milica G. | Jamilis, Laura | Johansson, Gunilla | Rodrigo Salas, Adrián | Rodríguez Gómez, Octavio | et al.

Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer’s Disease: A Randomized Controlled Trial—The OmegAD Study
Tofiq, Avin | Zetterberg, Henrik | Blennow, Kaj | Basun, Hans | Cederholm, Tommy | Eriksdotter, Maria | Faxén-Irving, Gerd | Hjorth, Erik | Jernerén, Fredrik | Schultzberg, Marianne | et al.

Alzheimer’s Disease-Related Neuropathology Among Patients with Medication Treated Type 2 Diabetes in a Community-Based Autopsy Cohort
Barthold, Douglas | Gibbons, Laura E. | Marcum, Zachary A. | Gray, Shelly L. | Dirk Keene, C. | Grabowski, Thomas J. | Postupna, Nadia | Larson, Eric B. | Crane, Paul K.

Niemann-Pick Type C 1 (NPC1) and NPC2 Gene Variability in Demented Patients with Evidence of Brain Amyloid Deposition
Sorrentino, Federica | Arighi, Andrea | Serpente, Maria | Arosio, Beatrice | Arcaro, Marina | Visconte, Caterina | Rotondo, Emanuela | Vimercati, Roberto | Ferri, Evelyn | et al.

Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline
Brenowitz, Willa D. | Zeki Al Hazzouri, Adina | Vittinghoff, Eric | Golden, Sherita H. | Fitzpatrick, Annette L. | Yaffe, Kristine

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Most Read Content in September 2021

Most read content via the IOS Press content website published in 2020 & 2021 JAD issues

MIND Diet, Common Brain Pathologies, and Cognition in Community-Dwelling Older AdultsOpen Access (Research Article in Vol.82, Iss.2, 2021) (View Press Release)
Dana, Klodian | James, Bryan D. | Agarwal, Puja | Aggarwal, Neelum T. | Cherian, Laurel J. | Leurgans, Sue E. | Barnes, Lisa L. | Bennett, David A. | Schneider, Julie A.

Neurobiology of COVID-19Openly Available (Review Article in Vol.76, Iss.1, 2020)
Fotuhi, Majid | Mian, Ali | Meysami, Somayeh | Raji, Cyrus A.

COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric ImplicationsOpen Access (Review Article in Vol.77, Iss.2, 2020)
Yamamoto, Vicky | Bolanos, Joe F. | Fiallos, John | Strand, Susanne E. | Morris, Kevin | Shahrokhinia, Sanam | Cushing, Tim R. | Hopp, Lawrence | Tiwari, Ambooj | Hariri, Robert | et al.

Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled TrialOpen Access (Research Article in Vol.83, Iss.4, 2021)
Cummings, Jeffrey | Schwartz, Gregory G. | Nicholls, Stephen J. | Khan, Aziz | Halliday, Chris | Toth, Peter P. | Sweeney, Michael | Johansson, Jan O. | Wong, Norman C.W. | et al.

A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and MicrobiologyOpen Access (Research Article in pre-press, 2021)
Allen, Herbert B.

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Journal of Alzheimer's Disease Reports

An Open Access Journal

The Journal of Alzheimer's Disease Reports – JAD's sister journal – is our online-only, fully open access journal for AD papers that gives equal weight to original research in basic science, translational research and clinical studies. We encourage direct submissions to Journal of Alzheimer's Disease Reports, taking advantage of the open access option and accelerated publication timeline (see instructions here).

Most read recent content published in the journal:

A Proposal to Make Biomedical Research into Alzheimer’s Disease More Democratic Following an International Survey with Researchers (Research Article in Volume 5, Online Aug 2021)
Daly, Timothy | Houot, Marion | Barberousse, Anouk | Petit, Amélie | Epelbaum, Stéphane

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study (Research Article in Volume 5, Online Jan 2021)
Dake, Manmohi D. | De Marco, Matteo | Blackburn, Daniel J. | Wilkinson, Iain D. | Remes, Anne | Liu, Yawu | Pikkarainen, Maria | Hallikainen, Merja | Soininen, Hilkka | Venneri, Annalena

Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease (Research Article in Volume 5, Online Apr 2021) (View Press Release)
Mold, Matthew John | O’Farrell, Adam | Morris, Benjamin | Exley, Christopher

Interdisciplinary and Transdisciplinary Perspectives: On the Road to a Holistic Approach to Dementia Prevention and Care (Review Article in Volume 4, Online Feb 2020)
Rodriguez (Then), Francisca S. | Jackson, Jonathan | Ware, Caitlin | Churchyard, Rebekah | Hanseeuw, Bernard

View all the content published in Q3, 2021 in Vol.5 here

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