NEW ISSUES

Volume 82, Issue 4 / 2021 Online

COVID-19 CONTENT
Mental Health of People with Dementia During COVID-19 Pandemic: What Have We Learned from the First Wave? – Openly Available
Borg, Céline | Rouch, Isabelle | Pongan, Elodie | Getenet, Jean Claude | Bachelet, Romain | Herrmann, Mathieu | Bohec, Anne-Lise | et al.

REVIEW ARTICLE
New Approaches to Profile the Microbiome for Treatment of Neurodegenerative Disease
Elmaleh, David R. | Downey, Matthew A. | Kundakovic, Ljiljana | Wilkinson, Jeremy E. | Neeman, Ziv | Segal, Eran

EDITOR'S CHOICE RESEARCH ARTICLES
Soluble Amyloid-β Consumption in Alzheimer’s Disease
Espay, Alberto J. | Sturchio, Andrea | Schneider, Lon S. | Ezzat, Kariem

Upregulation of Local Hepcidin Contributes to Iron Accumulation in Alzheimer’s Disease Brains (View Press Release)
Chaudhary, Suman | Ashok, Ajay | McDonald, Dallas | Wise, Aaron S. | Kritikos, Alexander E. | Rana, Neil A. | Harding, Clifford V. | Singh, Neena

Causes of Death in People with Dementia from 2002 to 2015: A Nationwide Study
Taudorf, Lærke | Nørgaard, Ane | Islamoska, Sabrina | Laursen, Thomas Munk | Waldemar, Gunhild

Association Between Season of Birth and Cognitive Aging in Older Adults: Pan-European Population-Based Study on 70,000 Individuals
Kucera, Matej | Wolfova, Katrin | Cermakova, Pavla

RESEARCH ARTICLES
Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer’s Disease – Open Access
Nara, Peter L. | Sindelar, Daniel | Penn, Marc S. | Potempa, Jan | Griffin, W. Sue T.

Potential Novel Genes for Late-Onset Alzheimer’s Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study – Open Access
Kang, Sarang | Gim, Jungsoo | Lee, Jiwoon | Gunasekaran, Tamil Iniyan | Choi, Kyu Yeong | Lee, Jang Jae | Seo, Eun Hyun | Ko, Pan-Woo | Chung, Ji Yeon | et al.

Volume 82, Issue 3 / 2021 Online

EDITORIAL
The FDA Approves Aducanumab for Alzheimer’s Disease, Raising Important Scientific Questions – Openly Available
de la Torre, Jack C. | Gonzalez-Lima, Francisco

COVID-19 CONTENT
Dementia and COVID-19, a Bidirectional Liaison: Risk Factors, Biomarkers, and Optimal Health Care – Openly Available
Toniolo, Sofia | Scarioni, Marta | Di Lorenzo, Francesco | Hort, Jakub | Georges, Jean | Tomic, Svetlana | Nobili, Flavio | Frederiksen, Kristian Steen | et al.

EDITOR'S CHOICE RESEARCH ARTICLES
Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy Bodies
Pilotto, Andrea | Imarisio, Alberto | Carrarini, Claudia | Russo, Mirella | Masciocchi, Stefano | Gipponi, Stefano | Cottini, Elisabetta | Aarsland, Dag | Zetterberg, Henrik | et al.

Segmented Linear Mixed Model Analysis Reveals Association of the APOEɛ4 Allele with Faster Rate of Alzheimer’s Disease Dementia Progression – Open Access
Chen, X. Richard | Shao, Yongzhao | Sadowski, Martin J. | for the Alzheimer’s Disease Neuroimaging Initiative

Hippocampal Functional Connectivity and Memory Performance After Exercise Intervention in Older Adults with Mild Cognitive Impairment – Open Access
Won, Junyeon | Callow, Daniel D. | Pena, Gabriel S. | Jordan, Leslie S. | Arnold-Nedimala, Naomi A. | Nielson, Kristy A. | Smith, J. Carson

Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer’s Disease Model
Paulo, Sara L. | Ribeiro-Rodrigues, Leonor | Rodrigues, Rui S. | Mateus, Joana M. | Fonseca-Gomes, João | Soares, Rita | Diógenes, Maria J. | Solá, Susana | et al.

Central Obesity, Cardiometabolic Risk, and Cognitive Change in the Study of Latinos – Investigation of Neurocognitive Aging
Stickel, Ariana M. | Tarraf, Wassim | Gonzalez, Kevin A. | Isasi, Carmen R. | Kaplan, Robert | Gallo, Linda C. | Zeng, Donglin | Cai, Jianwen | Pirzada, Amber | et al.

Porphyromonas gingivalis (W83) Infection Induces Alzheimer’s Disease-Like Pathophysiology in Obese and Diabetic Mice
Bahar, Bojlul | Kanagasingam, Shalini | Tambuwala, Murtaza M. | Aljabali, Alaa A.A. | Dillon, Stephanie A. | Doaei, Saeid | Welbury, Richard | Chukkapalli, Sasanka S. | Singhrao, Sim K.

Volume 82, Issue 2 / 2021 Online

EDITORIAL
New IDEAS Amyloid Imaging 2021 Study: Running in Place with Ineffective Anti-Amyloid Treatments for Alzheimer’s Disease Patients – Openly Available
Barrio, Jorge R. | Whitehouse, Peter | Alavi, Abass | Høilund-Carlsen, Poul F.

REVIEW ARTICLE
Benefits in Alzheimer’s Disease of Sensory and Multisensory Stimulation
Yang, Hong | Luo, Yinpei | Hu, Qingrong | Tian, Xuelong | Wen, Huizhong

EDITOR'S CHOICE RESEARCH ARTICLES
Polypharmacy and Cognition Function Among Rural Adults
Rasu, Rafia S. | Shrestha, Nistha | Karpes Matusevich, Aliza R. | Zalmai, Rana | Large, Stephanie | Johnson, Leigh | O’Bryant, Sid E.

Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study – Open Access
Xiao, Tian | Wijnant, Sara R.A. | Licher, Silvan | Terzikhan, Natalie | Lahousse, Lies | Ikram, M. Kamran | Brusselle, Guy G. | Ikram, M. Arfan

Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction – Open Access
Wei, Wei | Liu, Yinghua | Dai, Chun-Ling | Baazaoui, Narjes | Tung, Yunn Chyn | Liu, Fei | Iqbal, Khalid

The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
Babić Leko, Mirjana | Jurasović, Jasna | Nikolac Perković, Matea | Španić, Ena | Sekovanić, Ankica | Orct, Tatjana | Lukinović Škudar, Vesna | Bačić Baronica, Koraljka | et al.

Interaction Between APOE Genotype and Diabetes in Longevity
Shinohara, Mitsuru | Suzuki, Kaoru | Bu, Guojun | Sato, Naoyuki

Acute Exercise and Cognitive Function in Alzheimer’s Disease
Ben Ayed, Ines | Castor-Guyonvarch, Naomie | Amimour, Souad | Naija, Salma | Aouichaoui, Chirine | Ben Omor, Sana | Tabka, Zouhair | El Massioui, Farid

Research Attitudes and Interest Among Elderly Latinxs: The Impact of a Collaborative Video and Community Peers
Sewell, Margaret C. | Neugroschl, Judith | Umpierre, Mari | Chin, Shehan | Zhu, Carolyn W. | Velasco, Nelly | Gonzalez, Sabrina | Acabá-Berrocal, Alexandra | et al.

Cerebrospinal Fluid Sulfatide Levels Lack Diagnostic Utility in the Subcortical Small Vessel Type of Dementia
Svensson, Johan | Blomqvist, Maria | Kettunen, Petronella | Eckerström, Carl | Henricsson, Marcus | Jonsson, Michael | Bjerke, Maria | Månsson, Jan-Eric | Wallin, Anders

Near-Infrared Optical Spectroscopy In Vivo Distinguishes Subjects with Alzheimer’s Disease from Age-Matched Controls – Open Access
Greco, Frank A. | McKee, Ann C. | Kowall, Neil W. | Hanlon, Eugene B.

Relation of a Socioeconomic Index with Cognitive Function and Neuroimaging in Hypertensive Individuals
Paradela, Regina Silva | Ferreira, Naomi Vidal | Nucci, Mariana Penteado | Cabella, Brenno | Martino, Luiza Menoni | Torres, Laura Aló | Costa, Danielle Irigoyen da | et al.

Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study
Melo van Lent, Debora | O’Donnell, Adrienne | Beiser, Alexa S. | Vasan, Ramachandran S. | DeCarli, Charles S. | Scarmeas, Nikolaos | Wagner, Michael | et al.

Rats Display Sexual Dimorphism in Phosphorylation of Brain Tau with Age
Niu, Jiahui | Iqbal, Khalid | Liu, Fei | Hu, Wen

2021 Alzheimer Award Winners

JAD is pleased to announce that the 2021 Alzheimer Award goes to Giulio Taglialatela PhD, and Balaji Krishnan, PhD. This year’s award-winning article explores why certain individuals remain cognitively intact despite changes to the brain normally associated with fully symptomatic Alzheimer's disease (AD). “Understanding the involved cellular mechanism(s) would reveal a very effective target to develop a novel therapeutic concept for AD centered on inducing cognitive resistance in affected patients, explains Dr. Taglialatela. “Such therapy is expected to be effective in humans, as demonstrated by the existence of these resilient individuals.”

Each year, JAD’s Associate Editors select the article from the previous year’s volumes that has had the most significant impact on the field. The awardees receive an Alzheimer Medal, a 3-inch bronze medal with the likeness of Alois Alzheimer, and a cash prize of $7,500. This year’s award is proudly sponsored by Alzheimer's Germ Quest.

View the full press release here.

Open Access Winning Paper:
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers