NEW: Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease Guest Editor: Giulio M. Pasinetti, MD, PhD |  Discounted Print Book Price: €152 / US$187 / £137 | Order Your Print Copy at a 20% Discount* As a special offer to our readers and the AD community, you can now purchase the print book at a 20% discount. With its 732 pages and 40+ outstanding contributions, the Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease is currently available for a limited-time only at a discount price. Use the code below when ordering via our website before the end of Dec 2022 and you can get the print book for the discount price: €152 / US$187 / £137. Just place your order here before Dec 31, 2022 and enter the discount code listed below during the ordering process. DISCOUNT CODE: 20%AIAD9 *Discount only applies to the print version; include the eight digits of the code at checkout | About the Book The latest volume in our Advances in Alzheimer's Disease book series – brought to you by the Journal of Alzheimer's Disease – is a remarkable compilation of research that explores the complex role of the microbiome in Alzheimer’s disease. The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. About the Guest Editor Giulio M. Pasinetti, MD, PhD is the Chief of the Brain Institute Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, and the Saunders Family Chair and Professor in Neurology at the Icahn School of Medicine at Mount Sinai. He is also a JAD Senior Editor. Dr. Pasinetti’s research on lifestyle factors and metabolic co-morbidities, including diabetes, influencing clinical dementia, neurodegeneration ,and Alzheimer’s disease, has made him an expert in his field. Visit the webpage and discover all about the colorful visual that appears on the book's cover! | Preface Extract: Preface (Openly Available) by Giulio M. Pasinetti, MD, PhD "Research in the gut microbiota field has been rapidly evolving over the past decade. Despite being confined to the gastrointestinal tract, the impact of the gut microbiota biology on human physiology is extremely broad. The gut microbiota itself forms a powerful endocrine organ with a unique metabolome that supplements the host’s biochemistry beyond what it is designed to provide for itself: a perfect symbiotic relationship! These metabolites, and the breadth of gut microbiota cells themselves, interact with, and/or transverse the protective gut epithelial barrier influencing several physiological systems including the immune system, metabolism, neurological signaling and perhaps the most unexpectedly, the brain, giving rise to the gut-brain-axis. Collectively, this handbook contains four broad sections, each covering a pertinent research area pertaining to the overall literature on the gut-brain-axis and its relationship with cognitive functioning and AD. We hope that future research will be able to cohesively build upon the current foundation of rigorous studies by developing innovative and novel approaches that will progress our understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive functioning and AD." Full Preface | Highlighted Content: Discovery of Gut Bacteria Specific to Alzheimer’s Associated Diseases Is a Clue to Understanding Disease Etiology: Meta-Analysis of Population-Based Data on Human Gut Metagenomics and Metabolomics
Elena L. Paley Investigation of Potential Brain Microbiome in Alzheimer’s Disease: Implications of Study Bias
Susan Westfall, Duy M. Dinh, Giulio Maria Pasinetti A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s Disease
Miao Sun, Kai Ma, Jie Wen, Guangxian Wang, Changliang Zhang, Qi Li, Xiaofeng Bao, Hui Wang “Muscle-Gut-Brain Axis”: Can Physical Activity Help Patients with Alzheimer’s Disease Due to Microbiome Modulation?
Petr Schlegel, Michal Novotny, Blanka Klimova, Martin Valis Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease
Moira Marizzoni, Annamaria Cattaneo, Peppino Mirabelli, Cristina Festari, Nicola Lopizzo, Valentina Nicolosi, Elisa Mombelli, Monica Mazzelli, Delia Luongo, Daniele Naviglio, et al. New Approaches to Profile the Microbiome for Treatment of Neurodegenerative Disease
David R. Elmaleh, Matthew A. Downey, Ljiljana Kundakovic, Jeremy E. Wilkinson, Ziv Neeman, Eran Segal *Individual ebook chapters (PDF) can be purchased online at €27.50 / US$35.00/ £22.00 per item | You are receiving this mailing as you are signed up to receive news from JAD.
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