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NEW ISSUE

Dear Colleague,

We are delighted to announce the publication of Volume 8, Issue 2 of Bladder Cancer (BLC). This issue hosts an outstanding selection of content, including a review covering chromatin modifications and enzymes regulating these processes in bladder cancer, a short communication, six research articles, and two systematic reviews. From the editors of the regular journal sections, there are also new Challenging Case, Clinical Trials Corner, and Paper Alert contributions. All content is freely accessible and can be viewed via the links below.

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Call for Papers

As a member of our research community, we would like to invite you to contribute your own research articles to Bladder Cancer, which offers contributing authors many benefits:

• First class Editorial Board
• Rigorous peer review and speedy manuscript processing
• Rapid online publication (pre-press)

Submit your manuscript online via Editorial Manager
View detailed Instructions to Authors
Aims and Scope

We look forward to working with you.

Best wishes,

Editors-in-Chief

Seth P. Lerner, MD
Scott Department of Urology
Baylor College of Medicine
Houston, Texas, USA
Email: blc@iospress.com

Dan Theodorescu, MD, PhD
Samuel Oschin Comprehensive Cancer Institute
Cedars-Sinai Medical Center
Los Angeles, California, USA
Email: blc@iospress.com

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All content is currently freely available online to all readers

Review Article
Role of Chromatin Modifying Complexes and Therapeutic Opportunities in Bladder CancerOpen Access
Meghani, Khyati | Folgosa Cooley, Lauren | Piunti, Andrea | Meeks, Joshua J.

Short Communication
Reduced Dose Intravesical Bacillus Calmette-Guérin: Why It Might Not MatterOpenly Available
Kamat, Ashish M. | Lobo, Niyati | Lerner, Seth P. | Li, Roger | Matulay, Justin T. | Palou, Joan | Witjes, J. Alfred | Rouprêt, Morgan | Smith, Angela B. | Chang, Sam S. | Shore, Neal D. | et al.

RESEARCH ARTICLES
Head-to-Head Comparison between High-Resolution Microultrasound Imaging and Multiparametric MRI in Detecting and Local Staging of Bladder Cancer: The BUS-MISS ProtocolOpenly Available
Diana, Pietro | Lughezzani, Giovanni | Saita, Alberto | Uleri, Alessandro | Frego, Nicola | Contieri, Roberto | Buffi, Nicolomaria | Balzarini, Luca | D’Orazio, Federico | Piergiuseppe, Colombo | et al.

Association between Smoking and Overall and Specific Mortality in Patients with Bladder Cancer: A Population-based StudyOpenly Available
Ho, Chung-Han | Tseng, Wen-Hsin | Huang, Steven K. | Liu, Chien-Liang | Wu, Yu-Cih | Chiu, Allen W. | Ong, Khaa Hoo

The Impact of the COVID-19 Pandemic on Bladder Cancer Care in the NetherlandsOpenly Available
van Hoogstraten, Lisa M.C. | Kiemeney, Lambertus A. | Meijer, Richard P. | van Leenders, Geert J.L.H. | Vanneste, Ben G.L. | Incrocci, Luca | Smilde, Tineke J. | Siesling, Sabine | et al.

Comorbidity Scores and Machine Learning Methods Can Improve Risk Assessment in Radical Cystectomy for Bladder CancerOpenly Available
Wessels, Frederik | Bußoff, Isabelle | Adam, Sophia | Kowalewski, Karl-Friedrich | Neuberger, Manuel | Nuhn, Philipp | Michel, Maurice S. | Kriegmair, Maximilian C.

A New Functional Gene, Zinc Finger Protein 485 (ZNF485), is Involved in Bladder Cancer ProliferationOpenly Available
Tan, Yiao | Zhao, Fangfang | Liu, Shuhan | Huang, Tao | Zang, Chunbao | Sha, Dan | Kong, Lingsuo | Ge, Fangfang | Huang, Dabing | Pu, Youguang

A Phase 2 Study of S-588410 Maintenance Monotherapy for Platinum-Treated Advanced or Metastatic Urothelial CarcinomaOpen Access
Shimizu, Nobuaki | Hussain, Syed A. | Obara, Wataru | Yamasaki, Toshinari | Takashima, Satoru | Hasegawa, Takahiro | Iguchi, Motofumi | Igarashi, Kenji | Ogawa, Osamu | Fujioka, Tomoaki

Systematic Review
Efficacy of Surgery on the Primary Tumour in Patients with Metastatic Bladder Cancer: A Comprehensive ReviewOpen Access
Lim, Amy H. | Westerman, Mary E. | Korokovic, Andrea | Matulay, Justin T. | Narayan, Vikram M. | Navai, Neema

The Effect of Metformin on Bladder Cancer Incidence and Outcomes: A Systematic Review and Meta-AnalysisOpenly Available
van Hattum, Jons W. | de Ruiter, Ben Max | Oddens, Jorg R. | de Reijke, Theo M. | Wilmink, Johanna W. | Molenaar, Remco J.

Other Content
Challenging Cases in Urothelial Cancer: Case 24Openly Available
Soloway, Mark S. | Abrahams, Neil A.

Clinical Trials Corner Issue 8(2)Openly Available
Agarwal, Piyush K. | Sternberg, Cora N.

Implementing a New Standard of CareOpenly Available
Messing, Edward M.

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2022 YOUNG INVESTIGATOR AWARDS

Awardees recognized for novel, early career research

The Bladder Cancer Advocacy Network,(BCAN) has announced the recipients of its four Young Investigator Awards, presented to exceptional early career research scientists and clinical cancer investigators who have shown a commitment to improving the lives of bladder cancer patients..

Each award provides a $50,000 grant that supports one year of bladder cancer research. There were three recipients of the Young Investigator Award: Raie Bekele, PhD, an Instructor of Radiation Oncology at the Dana-Farber Cancer Institute; Laura Bukavina, MD, MPH, a Urologic Oncology Fellow at the Research Institute of Fox Chase Cancer Center; and Weisi Liu, PhD, a Post-doctoral Fellow in Hematology and Medical Oncology at the Weill Medical College of Cornell University. The 2022 Patient-Centered Clinical Research Young Investigator Award was awarded to Ava Saidian, MD, a Urologic Oncology Fellow at Moores Cancer Center at the University of California San Diego.

Read the full press release here; and click the visual below for the awardee profiles..

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Most Viewed BLC Articles in April & May 2022

Listing articles published only in 2021 and 2022 so you can read the most popular recent content)

Systematic Review and Meta-Analysis of Cisplatin Based Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer (Systematic Review in Vol.8, Iss.1, 2022) – Openly Available
Benkhadra, Raed | Nayfeh, Tarek | Patibandla, Sai Krishna | Peterson, Chelsea | Prokop, Larry | Alhalabi, Omar | Murad, M. Hassan | Mao, Shifeng S.

Sensitivity and Specificity in Urine Bladder Cancer Markers – Is it that Simple? (Article Commentary in Vol.8, Iss.1, 2022) – Openly Available
Roghmann, Florian | Goebell, Peter J. | Dyrskjøt, Lars | van Rhijn, Bas W.G. | Käfferlein, Heiko U. | Hakenberg, Oliver | Stenzl, Arnulf | Burger, Maximilian | Pesch, Beate | Benderska-Söder, Natalya | Schmitz-Dräger, Bernd J.

Accuracy of Inchworm Sign on Diffusion-Weighted MRI in Differentiating Muscle-Invasive Bladder Cancer (Research Article in Vol.8, Iss.1, 2022) – Openly Available
Kazan, Huseyin Ozgur | Culpan, Meftun | Gunduz, Nesrin | Keser, Ferhat | Iplikci, Ayberk | Atis, Ramazan Gokhan | Yildirim, Asif

Early Bone Metastases are Associated with Worse Outcomes in Metastatic Urothelial Carcinoma (Research Article in Vol.7, Iss.1, 2021) – Open Access
Nelson, Ariel A. | Cronk, Robert J. | Lemke, Emily A. | Szabo, Aniko | Khaki, Ali R. | Diamantopoulos, Leonidas N. | Grivas, Petros | Nezami, Behtash Ghazi | MacLennan, Gregory T. | et al.

The Impact of the COVID-19 Pandemic on Bladder Cancer Care in the Netherlands (Research Article in Vol.8, Iss.2, 2022) – Openly Available
van Hoogstraten, Lisa M.C. | Kiemeney, Lambertus A. | Meijer, Richard P. | van Leenders, Geert J.L.H. | Vanneste, Ben G.L. | Incrocci, Luca | Smilde, Tineke J. | Siesling, Sabine | et al.

Basal and Luminal Molecular Subtypes in Naturally-Occurring Canine Urothelial Carcinoma are Associated with Tumor Immune Signatures and Dog Breed (Research Article in Vol.7, Iss.3, 2021) – Openly Available
Sommer, Breann C. | Dhawan, Deepika | Ruple, Audrey | Ramos-Vara, José A. | Hahn, Noah M. | Utturkar, Sagar M. | Ostrander, Elaine A. | Parker, Heidi G. | Fulkerson, Christopher M. | et al.

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