Please feel free to forward to your colleagues and share the news of our journal | Dear Colleague, We are delighted to announce the publication of Volume 7, Issue 4 of Bladder Cancer (BLC). This issue hosts an outstanding selection of content, including an editorial, five research articles, and two systematic reviews. From the editors of the regular journal sections, there are also new Challenging Case, Clinical Trials Corner, and Paper Alert contributions. All content is freely accessible and can be can be viewed via the links below. Also enclosed is news from the Bladder Cancer Advocacy Network and a selection of our top viewed recent articles. We are also pleased to welcome Rebecca Barasky who has joined the board in the position of Associate Editor. | As a member of our research community, we would like to invite you to contribute your own research articles to Bladder Cancer, which offers contributing authors many benefits: • First class Editorial Board • Rigorous peer review and speedy manuscript processing • Rapid online publication (pre-press) Submit your manuscript online via Editorial Manager View detailed Instructions to Authors Aims and Scope We look forward to working with you. Best wishes, Editors-in-Chief Seth P. Lerner, MD Scott Department of Urology Baylor College of Medicine Houston, Texas, USA Email: blc@iospress.com Dan Theodorescu, MD, PhD Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles, California, USA Email: blc@iospress.com | All content is currently freely available online to all readers EDITORIAL The Pros and Cons of “Machination of Medicine” in Genitourinary Oncology Practice – Openly Available Pederzoli, Filippo | Bandini, Marco | Raggi, Daniele | Ross, Jeffrey S. | Spiess, Philippe E. | Necchi, Andrea BRIEF REPORT CD274 (PD-L1) Copy Number Changes (Gain) & Response to Immune Checkpoint Blockade Therapy in Carcinomas of the Urinary Tract – Openly Available Gupta, Sounak | Vanderbilt, Chad M. | Zhang, Yanming | Tickoo, Satish K. | Fine, Samson W. | Gopalan, Anuradha | Chen, Ying-Bei | Sirintrapun, Sahussapont J. | Teo, Min Yuen | et al. RESEARCH ARTICLES Impact of Neoadjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A Population Based Analysis – Openly Available Venkat, Siv | Lewicki, Patrick J. | Basourakos, Spyridon P. | Scherr, Douglas S. Real-World Study of Treatment with Pembrolizumab Among Patients with Advanced Urothelial Tract Cancer in Denmark – Open Access Omland, Lise Høj | Stormoen, Dag Rune | Dohn, Line Hammer | Carus, Andreas | Als, Anne Birgitte | Jensen, Niels Viggo | Taarnhøj, Gry Assam | Tolver, Anders | Pappot, Helle Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders – Open Access Nguyen, Khue G. | Wagner, Ethan S. | Vrabel, Maura R. | Mantooth, Siena M. | Meritet, Danielle M. | Zaharoff, David A. Cost of Care in Open Cystectomy Patients Across Time and Space: Does it matter? – Openly Available Sun, Helen H. | Prunty, Megan | Isali, Ilaha | Mahran, Amr | Ginsburg, Kevin | Markt, Sarah | Ponsky, Lee | Calaway, Adam | Bukavina, Laura SYSTEMATIC REVIEWS Optimizing Nutritional Status in Patients Undergoing Radical Cystectomy: A Systematic Scoping Review – Open Access Alam, Syed M. | Michel, Carrie | Robertson, Hilary | Camargo, Juliana T. | Linares, Brenda | Holzbeierlein, Jeffrey | Hamilton-Reeves, Jill M. Quality of Life following Chemoradiotherapy for Localized Muscle Invasive Bladder Carcinoma: A Systematic Review – Openly Available de Ruiter, Ben-Max | Keijzer, Abel N. | Hulshof, Maarten C.C.M. | Bins, Adriaan D. | de Reijke, Theo M. | Oddens, Jorg R. OTHER CONTENT Challenging Cases in Urothelial Cancer: Case 22 – Openly Available Soloway, Mark S. Clinical Trials Corner Issue 7(4) – Openly Available Agarwal, Piyush K. | Sternberg, Cora N. Paper Alert: Salvage for BCG Unresponsive and Recurrent Disease – Openly Available Messing, Edward M. | New Associate Editor: Rebecca Barasky, MPH We are pleased to welcome Rebecca Barasky, MPH to the Bladder Cancer editorial board in the position of Associate Editor. As BCAN’s Director of Research, Rebecca is responsible for the day-to-day operational oversight and management of all grant activities including application solicitation, grants management, investigator support, and analysis of program efficiency. Rebecca also manages BCAN grants from pre-award through award close-out while working closely with BCAN’s senior management to successfully achieve desired research outcomes. | BCAN to Offer Two Bladder Cancer Research Innovation Awards in 2022 The Bladder Cancer Advocacy Network (BCAN) will offer two Bladder Cancer Research Innovation Awards in 2022. This marks the second consecutive year that BCAN will grant two such awards to support experienced investigators with exceptionally novel and creative projects designed to produce significant advances in our understanding of the management of bladder cancer. Both awarded proposals will be funded for US$300,000 for two years. These awards support high risk, high reward projects with great potential to produce breakthroughs in our understanding of bladder cancer. The proposed research may be basic, translational, clinical or epidemiological and must have direct applicability and relevance to bladder cancer. Applications must include innovative approaches and new ideas to be eligible for funding. | Listing articles published only in 2020 & 2021 so you can read the most popular recent content In the World of Bladder Tumors: Size Does Matter (Research Article in Vol.6, Iss.2, 2020) Loloi, Justin | Allen, Jordan L. | Schilling, Amber | Hollenbeak, Christopher | Merrill, Suzanne B. | Kaag, Matthew G. | Raman, Jay D. Histologic Variants of Urothelial Carcinoma: Morphology, Molecular Features and Clinical Implications (Review Article in Vol.6, Iss.2, 2020) Alderson, Meera | Grivas, Petros | Milowsky, Matthew I. | Wobker, Sara E. FGFR3 – a Central Player in Bladder Cancer Pathogenesis? (Review Article in Vol.6, Iss.4, 2020) Knowles, Margaret A. Plasmacytoid Urothelial Carcinoma: Response to Chemotherapy and Oncologic Outcomes (Research Article in Vol.6, Iss.1, 2020) Diamantopoulos, Leonidas N. | Khaki, Ali Raza | Grivas, Petros | Gore, John L. | Schade, George R. | Hsieh, Andrew C. | Lee, John K. | Yezefski, Todd | Yu, Evan Y. | Schweizer, Michael T. | et al. Cost of Care in Open Cystectomy Patients Across Time and Space: Does it matter? (Research Article in Vol.7, Iss.4, 2021) Sun, Helen H. | Prunty, Megan | Isali, Ilaha | Mahran, Amr | Ginsburg, Kevin | Markt, Sarah | Ponsky, Lee | Calaway, Adam | Bukavina, Laura | Help Spread the News of BLC! | If you know of any colleagues or fellow researchers who are not yet signed up to receive the newsletter, we invite you to share this mailing with them. Click on the visual or access the sign-up link here. BLC has an active social media presence. If you are not yet interacting with the journal on social media, why not take the time today to follow us on Twitter? 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